When a case from ten years is re-opened, Allison finds herself in a chaotic situation. Things continue to get messier when Allison finds out that the convicted man is innocent, and that someone she knows and trusts may have been involved in his framing.
After Logan authorizes Palmer to take charge of the crisis, Palmer sanctions Jack and Curtis to infiltrate the Chinese Embassy on a covert operation to capture a suspect. Tony and Michelle continue to bump into each other's personal lives, while Buchanan expresses anger at being kept out of the mission. Jack faces Audrey's wrath when a medical dilemma places Paul's life in jeopardy.
Krypto and Ace take on a mutant dog-plant hybrid who is stealing all the trees in Metropolis.
There's a hysteria in America. A hysteria about what's become known as "the traditional family" and the desperate urgency to "save" it. And this rallying cry is not just coming from right wing conservatives and religious groups in the Red States (although, they're doing their share of tub-thumping.) The media (advertisers) and the government also have a vested interest in perpetuating the traditional concept of family: mother, father, two kids, dog and picket fence. But this hysteria is ignoring a key fact, the "traditional family" is bullshit. The traditional family structure may be for some, but it isn't for everyone. Shouldn't we stop trying to jam square pegs into round holes? Isn't it time for "Bullshit" to redefine the definition of "family?"
Mary meets her secret admirer but faces legal issues on the road to romance. When a philandering hotel guest (guest star Dave Foley) loses his wedding ring at a local brothel, Mike agrees to help him find it by investigating the establishment. Meanwhile, Danny and Ed do some investigating of their own to respect a friend's last wish for justice.
Evelyn reads in the obituaries that her second husband, Harry has died. They all attend the funeral, including Jake who is excited at the opportunity of seeing a ""dead guy"". Charlie is excited by the opportunity of a newly single widow, and Alan is just happy to pay his respects to Harry.
Ray's latest manipulative plan involves constantly turning down Debra in the bedroom.
A powerful sorceress switches bodies with Phoebe, who ends up trapped in the Underworld. Meanwhile, Paige faces a big problem when her new charge refuses her help.
Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.
Homer meets a new friend, Ray the Roofer, but gets confined to a mental institution when his friends and family believe he made him up.
When Bart endangers his health by bingeing on vending-machine food, the Simpsons turn their home into a hostel in order to afford sending him to a forced starvation facility.
Peter and Lois decide to go on a second honeymoon. But when Peter crashes the car, he decides to pose as Mel Gibson to stay in his fancy hotel suite, where they find a copy of a "The Passion of the Christ" sequel. They attempt to destroy the film and end up being chased by two priests who went to retrieve the film.
Izzie tries to get George to find the courage to ask Meredith out. All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship is also getting more complicated...
Wolcott draws Utter's ire during the questioning of a suspect. Merrick is overzealous in re-establishing his newspaper. Fields and Hostetler have little luck with a wild horse. Swearengen alters his agreement with Miss Isringhausen.
After Lois and Hal are reminded of the tight budget they must uphold, Hal discovers one of his boys has been dialing a 900 number. His attempt to explain the error to the hotline's billing department turns awry when he forgets to hang up the phone, incurring a whopping $800 charge. Meanwhile, Reese takes a job at a research clinic that pays him to pop experimental pills, and a reluctant Malcolm takes on a mortifying job at the Lucky Aide as a costumed Uncle Sam on stilts.
The boys hide all of the hash by using it to pave Ray's driveway. Ray's addiction to gambling and liquor gets worse. Ricky barbecues for his family with devastating effects.
When a pregnant nun is found dead, Jordan, Woody, and Nigel are thrown into this case of biblical proportions. Elsewhere, Dr. Macy is on the trail of a black widow. Will be prove her innocent or become her next victim.
A convicted serial killer will be paroled after 25 years in prison unless Lilly and her team can connect him to the 1977 murder of a young doorman found strangled on a train platform. The killing is eerily similar to other murders committed by the man. Making the case more urgent is the fact that the convicted strangler hints that he will kill again upon release. Elsewhere, Scotty confronts Christina about her past and tries to get her to talk to a New York detective.
Dana is stunned when she learns a big secret about her brother, Howie, at Gay Pride 2005. Mark tries to make amends with Jenny and Shane, Kit and Bette learn that their father, Melvin, is refusing treatment for his illness, and a shocking memory about Jenny's childhood is revealed.
When five young people are found dead by the tracks, Goren and Eames initially write them off as a suicide until their investigation reveals that one of the victims, Carmine Ruggiero, had no desire to be part of a suicide pact. Although initially they begin looking into a website that gives instructions on how to committ suicide, their investigation leads them to the unsolved suicide of Edie Elverson, one of Ruggiero's co-workers, whom he had once testifed against in a harrassment suit. Goren soon realises that another of the company's employees, Hubert Skoller, is trying very hard to push them to an answer.