Horrified to discover that Ephram and Madison are involved, Dr. Brown stops short of firing her, but Madison decides to quit leaving the Browns to a very unhappy holiday, especially when Delia discovers another troubling relationship - between her father and Linda Abbott. Stressed by Thanksgiving with his cantankerous mother-in-law (guest star Betty White), Dr. Abbott reacts badly when Amy brings Tommy (Paul Wasilewski) to Thanksgiving dinner. Finally pushed to the breaking point, Amy runs away from home.
A young woman is attacked by a shark and later dies, but it's discovered that she was shot first. The case becomes even more difficult for the CSIs when one of their coworkers becomes a leading suspect. The dead woman worked for a private-investigation agency that specializes in luring and entrapping married men suspected of infidelity.
Dee Dee's cousin Barbara comes to town for Big Dee Dee's baby shower, and stays with Mona because there is no room at Dee Dee's place. Mona is furious to learn from Barbara that Dee Dee shared things that Mona had told her in confidence about the effect her mother's bitterness has had on her feelings about marriage. Mona gives Dee Dee the silent treatment, but later has a talk with Phyllis about her fears. Big Dee Dee dreads the shower because she knows the guests will insist on touching her belly. Meanwhile, Spencer gets a makeover from Adam and some friends in the hopes of impressing Camille's social crowd.
When Flex falls for Sheila, an ambitious, sexy sports columnist, he is willing to do anything for her, including bribing Breanna to tutor her son Eric. But when Eric is caught stealing Flex's stories from his computer to give to his mother, Flex and Breanna team up to seek revenge.
Toni is furious to discover that Todd failed to deliver a message from a remorseful Greg before the wedding. Claiming that she needs closure but actually hoping to rub her happiness in Greg's face, she insists that she needs to meet with him. Todd fears that Toni still has feelings for Greg and threatens to leave her if she sees him. Toni declares that Todd needs to trust her; she ignores his ultimatum and meets with Greg anyway. Meanwhile, Joan is devastated when William's nephew/son cries every time she holds him, as she sees it a a sign that she wouldn't be a good mother. After Jabari tells Maya and Lynn that his classmates think they are lesbians, Maya angers Lynn by saying that she wouldn't even be her type.
Staff critiques vex Jack, who demands honesty and gets it, especially from servile Finch; a role reversal with Nina makes Maya a partygoer.
In jail after his escapade at Ellen's party, Geoffrey is visited by the ghost of his dead mentor Oliver, who cousels him on the danger of trying to ignore his past feelings for Ellen, the woman who once broke his heart. Meanwhile, Holly and Richard work on their merchandising scheme, which involves a Shakespeare themed village of retail stores. Geoffrey is finally forced to fire Darren as director, to the relief of the cast but the worry of the Board of Directors.
The day-to-day lives of three orphaned children who are adopted by aliens that have trouble adjusting to the local culture.
Matt and Sarah begin their student rotation in the ER, but get off to a bad start by arriving late and angering Dr. Norton, the attending ER physician. Matt and Sarah's relationship is tested when Matt quickly demonstrates an aptitude for the work, but Sarah accuses him of trying to make himself look better than the other students, especially her. However, Matt ends up looking foolish when he can't figure out how to turn off the ringer on his cell phone and he gets stuck fielding calls from his family. Matt's day ends tragically, leaving him to question his destiny.
Tired of all the bounty hunters and robots failing, Aku fights Jack, mano y mano.
When Nikki becomes Professor Oglevee's teaching assistant, she butts heads with the pretty young student who flirts with him for special treatment. Meanwhile, Kim, Stevie, T, Regina and Freddy compete for $5,000 by volunteering for a psych study in which they are forced to live for three days in cramped quarters.
Realizing he's losing someone special, Charlie plans a Thanksgiving dinner to convince her he's a family guy and that she should be with him.
Robert and Amy convince their families to spend Thanksgiving together. When the Barones arrive at the Pennsylvania home of Amy's parents, they find that their differing family traditions encourage lots of lively conversation.
When Sydney is taken into custody by the NSC, Jack and Vaughn have no choice but to ally themselves with Sloane to rescue her. But with only hours to spare before she is forced to undergo a radical surgery to recover her memories, they must put togther an extraction team, headed by freelance operative Brill (Richard Roundtree, "Shaft"). Meanwhile, Lauren faces an impossible choice -- side with the NSC, who she wants to believe is doing the right thing, or with her husband.
After making over $3000 from his own museum featuring a $1000 bill, Bart takes the family to London (on the suggestion of Grampa), where Homer is arrested for treason after crashing into the Queen.
Bianca, a woman from the future, arrives to take Chris's powers, and Leo learns that she is actually part of an assassin family of witches. Meanwhile, Paige decides to move in with Richard, while Phoebe ponders joining Jason in Hong Kong.
Rita Sue teaches a newcomer a few tricks of the trade. Balthus is nervous about Tommy Dolan's allegations. Lodz gets approval from Management to help Ben.
The FBI worries that an upcoming march could be the target of a possible terrorist attack. Sue tries to enlist Betty's help in trying to capture her husband. Jack and the gang find where the Bubonic Plague was stored and how Joseph maybe spreading it. As Betty learns more about her husband she understands that Sue was right about him.
Hilary Duff and her sister Haylie impersonate two members of the Shangri-Las, a '60s girl group, in an episode in which the Vietnam War gets in the way of JJ and Beth, and Meg and Drew (Sam Page), when they go on a ""double date"" to Harrisburg, where Roxanne's friend Lenny is playing with his band. Meanwhile, Uncle Pete's drinking is getting in the way of his relationship with Nancy (Alicia Coppola); Helen is concerned about Will's state of mind as he recovers from his operation; Sam's getting interested in Malcolm X; and Patty makes a friend.